WebNov 2, 2006 · A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 … Web序列中存在“Poly”结构，这个Poly结构是指什么960化工网专业团队、用户为您解答，有序列中存在“Poly”结构，这个Poly结构是指什么的疑问

A novel podophyllotoxin derivative with higher anti-tumor activity ...

Web4'-Demethylepipodophyllotoxin (4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly. For research use only. We do … photomath net worth

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WebCas No.: 40505-27-9 Formula: C 21 H 20 O 8 Mol Weight: 400.383 Botanical Source: Podophyllum emodi, Podophyllum polygama and other Podophyllum spp. also root of Dysosma majorense Purity: 95%~99% Analysis Method: HPLC-DAD or/and HPLC-ELSD Identification Method: Mass, NMR Packing: Brown vial or HDPE plastic bottle Web4'-Demethylepipodophyllotoxin is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly. Bioorg Med Chem. 2014 Jun 1;22 (11):2998-3007. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O- (2-pyrazinecarboxylic ... WebUsing the anti-tumor drug VP16 (demethylepipodophyllotoxin-beta-D-glucoside) with purified topoisomerase II, we identify twelve sites. Five sites are clustered around position -306 in a region that possesses enhancer-like properties. A second cluster of three sites is positioned 15 bp upstream of the TATA promoter element. how much are marchesa wedding dresses