WebAfter activation, STING is translocated from the ER via the ER-Golgi intermediate compartment (ERGIC) to the Golgi apparatus, where TBK1 and interferon regulatory factor 3 (IRF3) are recruited... WebOct 6, 2024 · IRF3 is activated downstream of all anti-viral PRRs through phosphorylation by IκB kinase (IKK)-related protein kinases, TANK-binding Kinase (TBK1) and IKKε, resulting in its dimerization and translocation into the nucleus in association with CREB-binding protein (CBP)/p300 to bind and transactivate the expression of target genes, such as TI-IFNs …
MAVS Gene - GeneCards MAVS Protein MAVS Antibody
WebMar 21, 2024 · Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed: 16125763, 16127453, 16153868, 16177806, … WebApr 17, 2015 · In the IRF3 gene, we can distinguish 3 variants of promoters in the human and mouse genomes. In humans two of these variants have a single binding site for IRF3 and … cost of a college education
Entry - *603734 - INTERFERON REGULATORY FACTOR 3; IRF3
WebMacrocyclization of the ATCUN Motif Controls Metal Binding and Catalysis Inorg. Chem, 2013, 52, 2729–2735. Neupane, K. P.; Aldous, A. R. and Kritzer, J. A.* Metallopeptide … Webmeasure C10 effects on dsRNA induction of IRF3 DNA binding. Green fluorescent protein-labeled IRF3 was used to measure C10 effects on dsRNA-induced IRF3 nuclear translocation. Native PAGE, SDS PAGE, and western blotting were used to identify effects of C10 on IRF3 homodimer formation and phosphorylation, respectively. There was a WebThe induction of type I interferons through the transcription factor interferon regulatory factor 3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) … breakfast with buddha series