Phosphopantetheine attachment site

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August undefined, 2024

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … WebJan 10, 2024 · To obtain active CAR enzyme, a phosphopantetheine group must be attached covalently to a conserved serine in the PCP domain mediated by a suitable …

Collaborative Biosynthesis of a Class of Bioactive ... - ResearchGate

Webphosphopantetheine (or pantetheine 4' phosphate) (Ppant) prosthetic group that is covalently attached to an invariant serine residue of the CP domain. CP domains, typically consisting of 70-100 residues, are either freestanding or embedded in these multifunctional proteins and exist as three variants: an Web[0005] This invention relates to a method of treatment, in particular to a method for lowering blood pressue levels in mammals and to compounds and compositions for use in such me how much sauerkraut to eat daily

Phylogenetic analysis of CARs. A) Domain organization of CAR …

WebDefinition: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. ID: GO:0000036 Synonyms: Articles referencing this term. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork ... WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. WebAcp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Pfam Domain Function. PP-binding ; Transmembrane Regions Not Available Cellular … how do seals sleep

Carboxylic acid reductase: Structure and mechanism - ScienceDirect

Weband acyl carrier protein [also known as a phosphopantetheine attachment site (PP) domains]. The KS, AT, and PP domains are essential for both FASs and PKSs, whereas the KR, DH, and ER domains are present in all FASs, but some or all are absent in various PKSs. KR, DH, and ER domains catalyze, in a stepwise WebJul 17, 2024 · The PCP Ser702, which serves as the phosphopantetheine attachment site, is positioned 52 Å away from the bound AMP phosphate. By contrast, ... how much sauerkraut should i eat dailyWebMay 28, 2010 · The amino acid sequence of NDRG1/Cap43 has been reported to bear a phosphopantetheine attachment site, an α/β hydrolase fold and three tandem repeats [15], [19], as well as a few sites that are phosphorylated by SGK [20] (Fig. 1 A). Western blotting revealed that NDRG1/Cap43 protein had several bands with different mobilities, including … how do seals refer to their ranks

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Phosphopantetheine attachment site

Phylogenomic analysis of type I polyketide synthase genes in …

WebPhosphopantetheine attachment site Provide feedback. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. WebPhosphopantetheine attachment site Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where …

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WebAug 23, 2024 · PDOC00012 1 Phosphopantetheine attachment site PDOC00013 1 Prokaryotic membrane lipoprotein lipid attachment site PDOC00342 1 Prokaryotic N … Web4'-Phosphopantetheine C11H23N2O7PS CID 115254 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ...

http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins ... which forms the 4′PPan cofactor attachment site. This α-helical region as well as two other α-helical segments (helix 1, residues 3–15 and helix 4, ...

WebFeb 20, 2024 · In addition, the phosphopantetheinylation of ACPs is dependent on the co-enzyme A, the PPT enzyme and the conserved serine residue in the phosphopantetheine attachment site (Supplementary Fig. 3 ... WebMar 23, 2024 · It has 12 putative transmembrane domains and intracellular N and C termini. SLC26A1 contains a sulfate transporter signature, a phosphopantetheine attachment site, …

WebJan 6, 2024 · The Psc_Aza_B gene is predicted to encode a non-reducing polyketide synthase composed of ve modules: ACP transacylase, β-ketoacyl synthase, acyltransferase phosphopantetheine attachment site and ...

Webthis effect was dependent upon an intact phosphopantetheine attachment site (PPAS) motif within the α/β hydrolase fold of NDRG1. Materials and Methods. Cell lines and culture. BeWo, JEG-3, CHO, and NIH3T3 lines were purchased from ATCC (Manassas, VA) and cultured as we previously detailed [38-41]. We also previously characterized and detailed the how much save for college calculatorWebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. GO:0009987: cellular process how much sausage gravy for 100 peopleWebOct 1, 2024 · Genome sequencing, comparative genomic analysis, and gene disruption of Streptomycessp. SYP-A7193 showed that the inthomycin biosynthetic gene cluster (itm) belonged to the hybrid polyketide synthase (PKS)/nonribosomal peptide … how much sauerkraut to eat per dayWebThe human NDUFAB1 protein contains a phosphopantetheine attachment site (DLGLDSLDQVEIIMAM), unique for acyl carrier proteins, and an EF-hand calcium binding … how much saved by 40WebSep 1, 2000 · Motifs I and III have been associated with ATP-binding and hydrolysis activities, respectively, since motif X contains a conserved serine to which a 4′-phosphopantetheine cofactor is very probably attached [ 3 ]. how do seals stay warmhttp://amigo.geneontology.org/amigo/term/GO:0000036 how much sauerkraut should you eat dailyWebPhosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for … how much sauerkraut to eat for gut health