Webb6 juni 2024 · Simvastatin is an oral HMG-CoA reductase inhibitor indicated as an adjunct to diet. It is a semi-synthetic derivative of lovastatin, the first FDA-approved statin. Simvastatin helps lower cholesterol production … Webb26 feb. 2024 · Based on high-quality evidence from randomized controlled trials (RCTs), high-intensity statin therapy should be instituted with a goal of lowering LDL-C levels by …
Moderate-Intensity Statins Plus Ezetimibe vs. High-Intensity …
Webb10 dec. 2024 · As mentioned, the ADA recommends moderate- and high-intensity statins for people with diabetes. In general, the ADA suggests using a lower potency statin for a person with diabetes only when they ... Webb1 okt. 2024 · Current Literature. In patients age 75 and younger, the efficacy of statins for primary prevention is well-established on the basis of multiple randomized trials, which … dag secondary messenger
Combined Statin-Ezetimibe for Elderly Adults With Atherosclerosis ...
Webb24 juni 2024 · Few subjects were treated with high-intensity statin therapy, with a maximum of 5.6% of subjects at 5years after HT. Changes in statin dose and intensity were frequent over subjects' clinical courses with the majority of subjects experiencing an increase in statin intensity over time. Webbhighest statin dose usage (none, low-moderate and high intensity) around diagnosis of PAD (within 1 year). The outcomes were risk of incident amputation (below knee or above knee) and mortality at 1, 3 and 5 years. The effect of statin dose on the two outcomes was also analyzed using Cox proportional hazards modeling to adjust for covariates. Webb30 nov. 2024 · Importantly, in a meta-analysis of the Cholesterol Trialists Collaboration, there was no increased risk of incident hemorrhagic stroke in high-intensity statin … bioclean lke